Abstract 10.35 SILK A VERSATILE BIOMATERIAL FOR CLINICAL TRANSLATION

Lyophilized Silk Sponges: A Versatile Biomaterial Platform for Soft Tissue Engineering

We present a silk biomaterial platform with highly tunable mechanical and degradation properties for engineering and regeneration of soft tissues such as, skin, adipose, and neural tissue, with elasticity properties in the kilopascal range. Lyophilized silk sponges were prepared under different process conditions and the effect of silk molecular weight, concentration and crystallinity on 3D sca...

Silk as a biomaterial paste for biomimetic composite

Natural biomaterial silk and silk proteins: Applications in tissue repair

Silk is a natural polymer synthesized and secreted by specialized silk gland of the silk worm. Silk is evolved as an ideal biomaterial can provide functional insight into relationships between polymer science and molecular biology. Silk proteins can be recovered from the silk during the processing chain of textile manufacture. The important characteristic of silk, especially the biocompatibilit...

Silk fibroin as biomaterial for bone tissue engineering.

UNLABELLED Silk fibroin (SF) is a fibrous protein which is produced mainly by silkworms and spiders. Its unique mechanical properties, tunable biodegradation rate and the ability to support the differentiation of mesenchymal stem cells along the osteogenic lineage, have made SF a favorable scaffold material for bone tissue engineering. SF can be processed into various scaffold forms, combined s...

Spider Silk as Guiding Biomaterial for Human Model Neurons

Over the last years, a number of therapeutic strategies have emerged to promote axonal regeneration. An attractive strategy is the implantation of biodegradable and nonimmunogenic artificial scaffolds into injured peripheral nerves. In previous studies, transplantation of decellularized veins filled with spider silk for bridging critical size nerve defects resulted in axonal regeneration and re...